All characters in Metal Gear Solid V have ‘lost something’
As many already know, ‘race’ and ‘revenge’ will be the main story themes in Metal Gear Solid V: The Phantom Pain. But another recurring theme will be the concept of loss: the phantom pain. This was explained on the Kojima Productions Alert 4, the official podcast of the studio.
Sean Eyestone, host of the studio’s podcast, explained: “All the characters somehow have lost something. This game is about that pain, that pain that they feel from losing, wether it’s a leg or an arm, or their voice or comrades.”
He also said that if you look at the trailer with that in mind, you start to notice some things that convey this theme: Skull Face losing his face, Quiet losing her voice.
“And there’s some hints.” he added. “That’s why we have those little character descriptions there.”
Source: KP Alert 4 (June 21 2013)

Snake lost his voice too.
paz lost his beautiful hair.
including other side characters like Strangelove?
btw will Cecile return? what about Amanda?
Not sure about them. It’s of course possible they be in this game, but we haven’t heard anything about them so far. Except Kojima supposedly mentioned Strangelove on the Japanese podcast, but I can’t check that myself.
I think Cecile was put in PW more like an intern joke than a real character. But Amanda could come back, since she is still Chico’s sister and BB rescues him in GZ
ehh it would be a shame if she just disappears like Natasha from MGS1 🙁
Snake has lost his mind
Ocelot has lost his purpose
Kaz has lost his limbs
Paz has lost her innocense
Chico has lost his life
Quiet has lost her voice
Emmerich has lost his morals
Snake lost his way in this huge open world
Kaz lost his sunglasses
Quiet lost her T-Shirt
Chico lost his Amanda
Emmerich lost his Strangelove
Ocelot lost his ocelot
Paz lost her intestines
Code Talker lost his botox
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